Abstract
In the present study, four fluoro-substituted benzoates of epi-gallocatechin (EGC) were prepared through a semisynthetic strategy, and the yield of benzylation of epi-gallocatechin gallate (−)-EGCG was improved by using freshly purified (−)-EGCG as starting material and a mild base of K2CO3. All structures of new compounds were characterized by 1H NMR, 13C NMR, high-resolution mass spectrometry, and optical rotation.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
This research is supported by Key International S&T Cooperation Projects (2009DFA32080) of the Ministry of Science and Technology of the People's Republic of China and by Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology. This project is also partly funded by the Special Fund for Marine Scientific Research in the Public Interest (201005024), and the Program for Changjiang Scholars and Innovative Research Team in University (IRT0944).