Concise and Alternative Synthesis of Zafirlukast, an Anti-Asthma Drug

Abstract

Concise and alternative synthesis of zafirlukast (1) is described. The synthesis features fewer steps, convergent synthesis, and novel intermediates.

GRAPHICAL ABSTRACT

Keywords:

• Alternate synthesis
• novel intermediates
• selective bromination
• zafirlukast

ACKNOWLEDGMENTS

The authors are thankful to the management of Dr. Reddy's Laboratories Ltd., IPDO Bachupally, for supporting this work. Cooperation from colleagues at Dr. Reddy's Laboratories Ltd., IPDO, Bachupally, in analytical research and development is appreciated.

Notes

Dr. Reddy's Communication No. IPDO-IPM-0000238.