Synthesis of O-Me Ulongamide B and O-Me Ulongamide C, Natural Modified Cyclodepsipeptides

Abstract

Synthesis of O-Me ulongamide B and O-Me ulongamide C, modified natural cyclodepsipeptides, was achieved by a convergent route. The respective dipeptides and tridepsipeptides were coupled, obtaining linear depsipentapeptides, which were then deprotected and cyclized. These compounds were tested against three different types of human carcinoma cells and showed only moderate activity.

GRAPHICAL ABSTRACT

Keywords:

• Anticancer drugs
• asymmetric synthesis
• cyclodepsipeptides
• marine natural products

Notes

^a IC₅₀ value is expressed as mean±SD of three independent experiments.

^b M-amsa (amsacrine) was used as a positive control.