Abstract
Novel pyrimido[4,5-b]quinoline-tetraones were prepared by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, 6-amino-uracils, and aromatic aldehydes in aqueous media and catalyzed by p-toluenesulfonic acid. This protocol provides a simple one-step procedure with the advantages of easy workup, good yield of products, and environmental friendliness.
GRAPHICAL ABSTRACT
Notes
Note. Reaction of 2-hydroxynaphthalene-1,4-dione, 4-chlorobezaldehyde, and 6-amino-uracil in the presence of p-TSA under reflux condition.
a Yields refer to isolated products.
a Yields refer to isolated products.