Ecofriendly Solventless Synthesis and Reduction Reaction of Some Triazole Compounds and Evaluation of Their Antimicrobial Activity

Abstract

A number of triazole-3-one compounds have been synthesized, and reduction of the carbonyl group in the molecule has been carried out to give a corresponding hydroxyl group that possesses asymmetric carbon atom in good yields and short reaction times. It is ecofriendly because it is produced by straightforward microwave irradiation in the absence of solvent. All newly synthesized compounds were also screened for their antimicrobial activities. The antimicrobial activity study revealed that 2d, 2i, 3c, and 3g–j showed good activity against a variety of microorganisms.

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GRAPHICAL ABSTRACT

Keywords:

• Antimicrobial activity
• green chemistry
• microwave-assisted synthesis
• solvent-free
• 1,2,4-triazole-3-one

ACKNOWLEDGMENT

Financial support from the Scientific and Technical Research Council of Turkey (TUBİTAK) through Project 108T221 is gratefully acknowledged.

Notes

^a 5 h at 170 °C.

^b 3 min at 150 °C.

^a 12 h at rt.

^b 2 min at 150 °C.

Notes. Ec, E. coli ATCC 25922; Yp, Y. pseudotuberculosis ATCC 911; Pa, P. aeruginosa ATCC 43288; Sa, S. aureus ATCC 25923; Ef, E. faecalis ATCC 29212; Bc, B. cereus 702 Roma; Ms, M. smegmatis ATCC607; Ca, C. albicans ATCC 60193; S. cerevisiae RSKK 251; Amp., ampicillin; Strep., streptomycin; Flu., fluconazole; —, no activity.