Improved Synthesis of Farinomalein and Its Analogs

Abstract

A practical and convenient synthesis of the fungicidal natural compound farinomalein is described starting from readily available ethyl 3-methyl-2-oxobutyrate and triethyl phosphonoacetate, employing a Horner–Wadsworth–Emmons condensation as the key step.

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GRAPHICAL ABSTRACT

Keywords:

• Antifungal
• farinomalein analogs
• natural compound
• synthesis

ACKNOWLEDGMENT

The authors gratefully acknowledge the University of Milan (FIRST funds) for financial support.

Notes

^a Minimum amount required for the inhibition of fungal growth on thin-layer chromatography plates (TLC).