Abstract
A general and efficient room-temperature procedure is developed for high-yield synthesis of 2H-benzo[b][1,4]thiazin-3(4H)-one derivatives in one pot from the reaction of 2-aminothiophenols with 2-bromoalkanoates in ionic liquid [bmim]NO3 without the use of any catalyst, base, or additive. Products were obtained in good yields by simple extraction with Et2O followed by evaporation of the volatile contents and recrystallization from Et2O. The ionic liquid was recycled and reused in the next reaction without the loss of its activity.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
The authors gratefully thank the Iran National Science Foundation (INSF) for financial support of this work (Project 88000118).
Notes
a Isolated yields.
a Isolated yields.
a N-Methylpiperidine.