Ionic Liquid Containing Copper(I): A New, Green, Homogeneous, and Reusable Catalyst for Click Cyclization

Abstract

An ionic liquid containing copper(I) is introduced as a new, green, homogeneous, and reusable catalyst for click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from α-azido ketones and terminal alkynes in various solvents, especially in [bmim]BF₄. These cyclization reactions were efficiently performed in the presence of introduced ionic liquid catalyst with short reaction times and good yields. This catalytic ionic liquid exhibits excellent activity and can be simply recovered and reused for at least five runs without any loss in its activity.

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GRAPHICAL ABSTRACT

Keywords:

• Click chemistry
• ionic liquid
• multicomponent
• organic azide
• triazole

ACKNOWLEDGMENT

The authors gratefully acknowledge the Research Council of Shahid Chamran University for financial support.

Notes

^a Yield refers to isolated and pure products.

^a Yields refer to isolated and pure products.

^a Yields refer to isolated and pure products.