Efficient Bakers’ Yeast-Catalyzed Multicomponent Synthesis of α-Aminophosphonates in One Pot

Abstract

Utilizing bakers’ yeast (Saccharomyces cerevisiae) as a biocatalyst, synthesis of α-aminophosphonates in one pot has been accomplished by the three-component reaction of an aldehyde, an amine, and diethyl phosphite in moderate to good yields under solvent-free reaction conditions.

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GRAPHICAL ABSTRACT

Keywords:

• Aldehydes
• amines
• α-aminophosphonates
• green chemistry
• Saccharomyces cerevisiae
• solvent-free conditions

ACKNOWLEDGMENTS

A. K. B. is grateful to the Department of Biotechnology (DBT), Government of India, New Delhi, India, for financial support. Authors are grateful to the late M. I. Khan, senior principal scientist, Division of Biochemical Sciences, for fruitful discussions.

Notes

^a All products were characterized by ¹H NMR, ¹³C NMR, and mass spectral data.

^b Isolated yields of the corresponding α-aminophosphonates.