Direct Synthesis of Nitriles from Aldehydes Using Chloramine-T/KI in Aqueous Ammonia

Abstract

A convenient method for direct conversion of aldehydes into nitriles has been developed using chloramine-T/KI in aqueous ammonia.

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GRAPHICAL ABSTRACT

Keywords:

• Aldehydes
• aqueous ammonia
• chloramine-T
• nitriles
• oxidation

Notes

^a Reaction conditions: aldehyde (2 mmol), aqueous ammonia (10 mL), THF (1 mL), rt, 1.5 h.

^b Isolated yields.

^a Reaction conditions: aldehyde (2 mmol), aqueous ammonia (10 mL), THF (1 mL), chloramine-T (3 mmol), KI (3 mmol), rt.

^b Isolated yields.