Abstract
The development of new strategies for synthesis of medium-sized O-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in oxygen-containing seven- and higher-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of O-heterocycles. The literature data are summarized based on the size of cycles.