One-Pot Synthesis of Novel 2-(Thiazol-2-yl)-4,5-dihydropyridazin-3(2H)-one Derivatives Catalyzed by Activated KSF

Abstract

A series of 2-(thiazol-2-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by one-pot multicomponent cyclocondensation of ketoacid, thiosemicarbazide, and phenacyl bromide using catalytical amount of KSF in EtOH under reflux. The straightforward synthesis, presence of two important class of heterocyclic rings in the individual molecule, easy workup of the products, rapid reaction, mild conditions, and good to excellent yields are notable features of this protocol.

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GRAPHICAL ABSTRACT

Keywords:

• KSF
• multicomponent
• pyridazinone
• regioselective
• 2-(thiazol-2-yl)-4,5-dihydropyridazin-3(2H)-one
• thiazole

ACKNOWLEDGMENT

The authors are grateful to the Research Council of University of Guilan for the financial support of this research work.