Abstract
A Pd-catalyzed decarboxylative coupling of substituted benzoic acids with phenylboronic acid has been developed. Under the optimized conditions, a variety of substituted benzoic acids were found to undergo decarboxylative coupling with various phenylboronic acids to give the desired unsymmetrical biaryls in good yields.
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GRAPHICAL ABSTRACT
Notes
a All reactions were carried under dry nitrogen atmosphere at 130 °C for 12 h.
b Yields were determined by GC.
a All reactions were carried out under dry nitrogen atmosphere using 10 mol% PdCl2, 3 equiv Ag2CO3, and 20 mol% PPh3 in DMSO/DMF (9/1, 6 mL/mmol) at 130 °C for 12 h.
b Isolated yields.