Green, One-Pot, Multicomponent Synthesis of Fused-Ring 2-Aminothiazoles

Abstract

A facile, green, and efficient Fe(III) chloride, one-pot, multicomponent reaction (MCR) for synthesis of 2-aminothiazole-based compounds is reported. Considering the medicinal importance of fused ring 2-aminothiazoles, this process provides an easy route to the synthesis of this class of compound. Detailed mechanism of the reaction has been discussed.

GRAPHICAL ABSTRACT

Keywords:

• 2-Aminothiazole
• iron(III) catalyzed
• MCR

ACKNOWLEDGMENTS

The authors are grateful to SAIF, Kochin, SAIF, NEHU and CIL, Assam University, for spectral studies.

Notes

^a Secondary amine used.

^a Secondary amine used.

^a Secondary amine used.

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