Simple and Efficient Synthesis of 5-Substituted-3-phenyl-2-thioxoimidazolidin-4-one Derivatives from S-Amino Acids and Phenylisothiocyanate in Et₃N/DMF-H₂O

Abstract

A concise approach for the transformation of various S-amino acids into the 5-alkyl-3-phenyl-2-thioxoimidazolidin-4-one heterocycles using phenylisothiocyanate is described. Phenylthiohydantoins of amino acid were synthesized at room temperature in Et₃N/DMF-H₂O with easy workup and excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• Amino acids
• cyclization
• phenylisothiocyanate
• 2-thiohydantoin

ACKNOWLEDGMENT

The authors are thankful to SAIF, Punjab University, Chandigarh, for providing the spectral analysis.

SUPPLEMENTAL MATERIAL

Supplementary material includes experimental details, characterization data of all compounds, and FT-IR, ¹H NMR, ¹³C NMR, and mass spectra for this work, which can be accessed on the publisher’s website.