Synthesis of Novel Derivatives of Benzoxazole in Bis-Ionic Liquid [BDBDIm]Br

Abstract

Bis-ionic liquid 3,3-(butane-1,4-diyl)bis(1,2-dimethyl-1H-imidazole-3-ium)bromide ([BDBDIm]Br) was found to be an effective catalyst for the synthesis of novel benzoxazoles using different salicylic acid derivatives and 2-amino-4-chlorophenol at room temperature. The present methodology offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions, and reduced environmental consequences. The ionic liquid was recovered and reused. All of synthesized compounds were characterized by infrared (IR), NMR, and elemental analyses.

GRAPHICAL ABSTRACT

Keywords:

• Benzoxazoles
• bis-ionic liquid
• room temperature
• salicylic acid

Supplemental Material

Full experimental details, ¹H and ¹³C NMR spectra, and elemental analyses for this article can be accessed on the publisher’s website.