Simple and Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles from θ-Diaminoarene and Aryl Aldehydes

Abstract

An easy and efficient one-pot condensation method for the synthesis of substituted benzimidazoles from θ-phenylenediamines with aryl aldehydes using urea hydrogen peroxide (UHP) and I₂ in dimethylsulfoxide (DMSO) provides wide substrate scope with good to excellent yields and simple and quick isolation of the products.

GRAPHICAL ABSTRACT

Keywords:

• Aldehydes
• benzimidazole
• θ-diaminoarene
• iodine
• urea hydrogen peroxide

ACKNOWLEDGMENT

We are grateful to Saratchandra Babu, GITAM University, for editorial suggestions.

SUPPLEMENTAL MATERIAL

Supplemental data for this article can be accessed on the publisher’s website.