Catalyst-Free Preparation of Heterocyclic Thienyl Sulfides

Abstract

Described in this work is a catalyst-free, in most cases neat, preparation of heterocyclic thienyl sulfides. This method utilizes 2-thiophenethiol and various activated halogenated heterocycles in a substitution-type reaction to form an interesting array of sulfides. Yields obtained are comparable to other published methods, and the reaction requires milder conditions, has shorter reaction times, and most times eliminates the need for column chromatography during workup.

GRAPHICAL ABSTRACT

Keywords:

• Catalyst
• heterocyclic
• sulfide
• thienyl

SUPPLEMENTAL MATERIAL

Full experimental details and ¹H and ¹³C NMR spectra for this article can be accessed on the publisher’s website.