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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 3
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Original Articles

Green and highly efficient synthesis of pyranopyrazoles in choline chloride/urea deep eutectic solvent

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Pages 220-225 | Received 23 Aug 2015, Published online: 06 Feb 2016
 

ABSTRACT

A simple and efficient multicomponent protocol, using ammonium deep eutectic solvent as a dual catalyst and environmentally benign reaction medium, is developed for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. This operationally simple protocol does not involve tedious workup or purification, affording the target compounds in short reaction times and excellent yields and avoiding the use of environmentally hazardous solvents and catalysts.

GRAPHICAL ABSTRACT

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