Simple and efficient synthesis of benzofuran derivatives from tyrosol

Paolo BovicelliC.N.R. Institute of Biology and Molecular Pathologies (IBPM), Department of Chemistry, Sapienza University of Rome, Rome, ItalyCorrespondence[email protected]

Fabrizio BottaroC.N.R. Institute of Biology and Molecular Pathologies (IBPM), Department of Chemistry, Sapienza University of Rome, Rome, Italy

Carla SappinoC.N.R. Institute of Biology and Molecular Pathologies (IBPM), Department of Chemistry, Sapienza University of Rome, Rome, Italy

Michela TomeiC.N.R. Institute of Biology and Molecular Pathologies (IBPM), Department of Chemistry, Sapienza University of Rome, Rome, Italy

Valentina NardiC.N.R. Institute of Biology and Molecular Pathologies (IBPM), Department of Chemistry, Sapienza University of Rome, Rome, Italy

Ilaria Proietti SilvestriC.N.R. Institute of Biology and Molecular Pathologies (IBPM), Department of Chemistry, Sapienza University of Rome, Rome, Italy

Beatrice MacchiDepartment of System Medicine, “Tor Vergata” University, Rome, Italy

Caterina FrezzaDepartment of System Medicine, “Tor Vergata” University, Rome, Italy

Giuliana RighiC.N.R. Institute of Biology and Molecular Pathologies (IBPM), Department of Chemistry, Sapienza University of Rome, Rome, Italy

show all

ABSTRACT

A convenient strategy for the preparation of compounds bearing the benzofuran skeleton starting from tyrosol, a phenol largely present in olive oil production waste, with no biological importance, is reported. A bromination/methoxylation sequence, already described for the synthetic transformation of naturally occurring compounds, was exploited. Depending on the solvent used for the methoxylation reaction together with the presence of a 4-phenol moiety respect to the side chain, benzodihydrofurans or a benzofurans derivative can be obtained.

GRAPHICAL ABSTRACT

KEYWORDS:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Simple and efficient synthesis of benzofuran derivatives from tyrosol

Information for

Open access

Opportunities

Help and information

Simple and efficient synthesis of benzofuran derivatives from tyrosol

ABSTRACT

GRAPHICAL ABSTRACT

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature