Sequential change in one-pot, three-component protocol: A stepping stone in heterocyclic synthesis

Ranganathan RajaDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India

Dinesh MuruganDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India

Archana SivasubramaniyanDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India

Jaabil GeorgeDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India

Sakthivel PerumalDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India

Ponnuswamy AlagusundaramDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, IndiaCorrespondence[email protected]

Mohan Raj JayakumarDepartment of Physics, Thanthai Periyar Government Institute of Technology, Vellore, Tamilnadu, India

Murugavel SaminathanDepartment of Physics, Thanthai Periyar Government Institute of Technology, Vellore, Tamilnadu, India

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ABSTRACT

Two different heterocycles, thiazole-2-imines and imidazole-2-thiones, have been conveniently synthesized by just altering the sequential order (1 + 2 + 3 or 1 + 3 + 2) when combining the same components [aryl amine (1), aryl isothiocyanate (2), and phenacyl bromide (3)] in one-pot, three-component protocols. The third possible sequential order of combination (2 + 3 + 1) chemoselectively affords thiazole-2-imine. The finding is a stepping stone in the synthetic applicability of sequential one-pot, three-component protocols.

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Sequential change in one-pot, three-component protocol: A stepping stone in heterocyclic synthesis

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Sequential change in one-pot, three-component protocol: A stepping stone in heterocyclic synthesis

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