Cu(I)-promoted one-pot click-S_NAr reaction of nitrobenzaldehydes

ABSTRACT

A series of 1,4-disubstituted 1,2,3-triazoles containing formyl was synthesized from a variety of readily available nitrobenzaldehydes and alkynes via a convenient one-pot, click-S_NAr reaction with moderate to excellent yields. The reactions were easily carried out in hexamethyl phosphoramide in the absence of a base at 60 °C.

GRAPHICAL ABSTRACT

KEYWORDS:

• Click chemistry
• copper catalysis
• heterocycle
• 1,2,3-triazoles

Acknowledgment

This work was supported by the Natural Science Fund for Colleges and Universities in Jiangsu Province (15KJD350001) and the subject of Twelfth Five-Year-Plan of Jiangsu Open University (14SEW-Y-006).