Ultrasound-assisted synthesis of diversely functionalized tetrahydro-1H-Indole-4(5H)-one using Brønsted base silica sodium carbonate (SSC) as a catalyst under solvent-free conditions

Vijay Vilas ShindeDepartment of Image Science and Engineering, Pukyong National University, Busan, Republic of Korea

Seung Min LeeLED Convergence Engineering Department, Specialized Graduate School Science and Technology Convergence, Pukyong National University, Busan, Republic of Korea

Jeong Su OhDepartment of Image Science and Engineering, Pukyong National University, Busan, Republic of Korea

Kwon Taek LimDepartment of Image Science and Engineering, Pukyong National University, Busan, Republic of Korea

Yeon Tae JeongDepartment of Image Science and Engineering, Pukyong National University, Busan, Republic of KoreaCorrespondence[email protected]

ABSTRACT

An ultrasound-promoted, environmentally benign, efficient procedure has been developed for the synthesis of biologically active tetrahydro-1H-indol-4(5H)-one using heterogeneous Brønsted base silica sodium carbonate (SSC) as a catalyst under solvent-free conditions. In comparison to the conventional methods, this efficient green protocol provides remarkable advantages such as good to excellent yields, shorter reaction time, low cost, and easy workup procedure and bypasses the use of hazardous transition-metal catalysts and organic solvents.

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Ultrasound-assisted synthesis of diversely functionalized tetrahydro-1H-Indole-4(5H)-one using Brønsted base silica sodium carbonate (SSC) as a catalyst under solvent-free conditions

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Ultrasound-assisted synthesis of diversely functionalized tetrahydro-1H-Indole-4(5H)-one using Brønsted base silica sodium carbonate (SSC) as a catalyst under solvent-free conditions

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