Efficient and convenient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline

ABSTRACT

An efficient, four-component, one-pot condensation reaction of phthalimide or phthalic anhydride, aromatic aldehydes, and ethyl cyanoacetate for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline in excellent yields is reported.

GRAPHICAL ABSTRACT

KEYWORDS:

• Ethyl cyanoacetate
• multicomponent reactions
• one-pot synthesis
• organocatalyst
• phthalic anhydride
• phthalimide
• pyrazolo[1,2-b]phthalazine-5-dione

Acknowledgments

We gratefully acknowledge to the Department of Chemistry, University of Rajshahi, Bangladesh for the facility given during our present work and to the Green Chemistry Laboratory, KRICT, for the necessary spectral help.