Efficient and green microwave-assisted one-pot synthesis of azaindolizines in PEG-400 and water

ABSTRACT

A facile, convenient, environmentally benign, and one-pot synthesis of imidazo[1,2-a]pyridines from 2-aminopyridines and in-situ generated phenacyl bromides under microwave irradiation in polyethylene glycol (PEG-400) and water (1:2) has been developed. The protocol provides a better alternative to the existing method as it involves utilization of in-situ-generated α-bromoacetophenones, avoids the use of lachrymatric α-haloketones as well as volatile toxic organic solvents, and reduces the reaction time to obtain excellent yield.

GRAPHICAL ABSTRACT

KEYWORDS:

• 2-Aminopyridines
• imidazo[1,2-a]pyridines
• microwave irradiation
• NBS
• PEG-400–water

Acknowledgement

We are thankful to the principal, Vivekanand College, Aurangabad, for supporting this research work by providing the infrastructure at the college central research facility.