Recent progress in the synthesis of diclofenac based NSAIDs analogs/derivatives

Freeha HafeezDepartment of Chemistry, Government College University, Faisalabad, Pakistan;

Ameer Fawad ZahoorDepartment of Chemistry, Government College University, Faisalabad, Pakistan; Correspondence[email protected] [email protected]

Sajjad AhmadDepartment of Chemistry, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad, Pakistan

Matloob AhmadDepartment of Chemistry, Government College University, Faisalabad, Pakistan;

Sadia FaizDepartment of Chemistry, Government College University, Faisalabad, Pakistan;

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are known for inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Diclofenac and its analogs, having phenylacetic acid moiety, are important NSAIDs. In this review article, various methodologies developed after 90 s for the synthesis of various analogs/derivatives of diclofenac sodium have been discussed and summarized.

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Acknowledgments

The authors are thankful to Government College University Faisalabad, UET Lahore FSD Campus and Higher Education Commission, Pakistan for providing facilities to carry out this work.

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Recent progress in the synthesis of diclofenac based NSAIDs analogs/derivatives

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