Coumarin-1,2,3-triazole hybrid derivatives: Green synthesis and DFT calculations

Abstract

A series of new 1,2,3-triazole-coumarin hybrid system are synthesized from the click reaction between 3-azido coumarin and different aromatic terminal alkyne derivatives in a green manner. All compounds are characterized by IR, NMR and UV-VIS spectroscopy. The experimental observations are further supported by DFT computational studies to investigate the effect of substituents at para position in these compounds.

Graphical Abstract

Keywords:

• 1,2,3-Triazole
• copper (I) catalyst
• CuAAC
• Green synthesis
• DFT calculation

Additional information

Funding

This work was supported and funded by a grant from the Research Council of Tehran University of Medical Sciences (TUMS).