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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 3
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Articles

Design and synthesis of cage-like NADH model molecule intermediate with multi-chiral centers

Tong ZhangTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences Chinese Academy of Sciences, Beijing, China; View further author information
,
Cui-Bing BaiTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences Chinese Academy of Sciences, Beijing, China; View further author information
,
Yue-Hua WuTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences Chinese Academy of Sciences, Beijing, China; View further author information
,
Nai-Xing WangTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences Chinese Academy of Sciences, Beijing, China; Correspondence[email protected]
View further author information
,
Bao-Cai XuSchool of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China; View further author information
,
Zhan YanTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences Chinese Academy of Sciences, Beijing, China; View further author information
&
Yalan XingDepartment of Chemistry, William Paterson University of New Jersey, Wayne, NJ, USAView further author information
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Pages 410-416 | Received 05 Nov 2018, Accepted 04 Dec 2018, Published online: 29 Jan 2019
 
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Abstract

Studying NADH molecules is one of the most active areas in biomimetic research. It is important to design novel and efficient chiral NADH model molecules. Herein, a cage-like NADH model with multi-chiral centers was designed, and key intermediates have been synthesized. In this study, we found that pentafluorophenoxy group is an excellent leaving group for our synthetic route.

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Additional information

Funding

Support for this research was provided by the National Natural Science Foundation of China (21676003).

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