Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik-Fields reaction applying amides as the starting materials

Anna TripolszkyDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary;

http://orcid.org/0000-0002-3223-7315 View further author information

Lili ZobokiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary; View further author information

Erika BálintDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary;

http://orcid.org/0000-0002-5107-7089 View further author information

János KótiGedeon Richter Plc, Budapest, Hungary

http://orcid.org/0000-0002-3021-3002 View further author information

György KeglevichDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary; Correspondence[email protected]

http://orcid.org/0000-0002-5366-472X View further author information

Abstract

A series of acylated α-aminophosphine oxides were synthesized by the microwave-assisted Kabachnik-Fields reaction of a series of carboxylic acid amides, formaldehyde and secondary phosphine oxides. To compensate the lower reactivity of the -NH₂ reagents, they had to be used in an excess. The solvolytic condensations furnished the α-aminophosphine oxides in yields of 58-93% after purification by chromatography.

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The authors are indebted to the National Research, Development and Innovation Fund [No K119202] for financial support.

Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik-Fields reaction applying amides as the starting materials

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Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik-Fields reaction applying amides as the starting materials

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