Facile synthesis of 3-aryl benzofurans, 3-aryl benzothiophenes, 2-aryl indoles and their dimers

Abstract

The preparation of 3-aryl benzofuran and benzothiophenes and their dimers at 2-position and, 2-aryl indoles and their 3-position dimers preparation is described.

Graphical Abstract

Keywords:

• Aluminum chloride
• 3-aryl benzofurans
• 3-aryl benzothiophenes
• 2
• 2′-bis (3
• 3′-aryl benzofurans and thiophenes)
• 3
• 3′–bis (2
• 2′–aryl indoles)
• ferric chloride

Supporting information

Full experimental detail, ¹H and ¹³C NMR spectra, HRMS traces. This material can be found via the “Supplementary Content” section of this article’s webpage.

Acknowledgment

We would like to thank Suven life sciences for providing excellent analytical facilities and our CEO, Mr. Jasti for allowing us to publish this work.

Additional information

Funding

Financial Support for This Work Was Provided by the Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), Doctoral Fellowships from the National Science Foundation (S.A.S.) and the Department of Defense (J.A.P.), and Grants from Abbott, Amgen, Boehringer - Ingelheim, Glaxo, Hoffmann - La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.