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A concise synthesis of key isoxazole-based side chain of Micafungin, an USFDA approved anti-fungal agent, has been delineated. The route design notably involves a one pot regioselective isoxazole construction from the corresponding aryl aldehyde and alkyne intermediates.
We thank Dr. Reddy’s Institute of Life Sciences for its support. We thank Mahesh Tammineni for his help in synthesis of compound 12.
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