Oxone-sodium nitrite mediated N-nitrosamines formation under mild conditions from secondary amines

Abstract

Herein, we report an efficient synthesis of N-nitrosamines from cyclic, aliphatic, benzylic, and aromatic secondary amines via a novel straightforward, efficient, and mild chemical process using sodium nitrite and Oxone in methanol as a solvent at 0–5 °C. The demonstrated methodology accounts well for the parameters like cost-effective, short reaction time, clean and safe handling along with good to excellent yields.

Graphical Abstract

KEYWORDS:

• N-nitrosamines
• Oxone
• secondary amines
• sodium nitrite

Acknowledgment

We thank the Defence Institute of Advanced Technology (DU) for providing infrastructural support. Research grant from “DIAT– Internal project on burn rate modifiers” is gratefully acknowledged. P.G. thanks CSIR-UGC, New Delhi, India for providing the fellowship.

Additional information

Funding

We thank the Defence Institute of Advanced Technology (DU) for providing financial support.