Abstract
In this study, first, a series of chalcone compounds S1–S6 were synthesized from various acetophenone derivatives (acetophenone, p-methyl acetophenone, and p-methoxy acetophenone) and aromatic aldehyde derivatives (benzaldehyde, p-methyl benzaldehyde, and p-methoxy benzaldehyde) by the Claisen–Schmidt condensation reaction. These S1–S6 compounds were then used in the preparation of 4,5-dihydropyrazol-1-yl derivatives S7–S15. Finally, four new compounds S16–S19 were synthesized from compound (S7, S8, S9, and S12) and 2,4-dinitrophenylhydrazine. Therefore, three known and ten new heterocyclic compounds were synthesized and completely characterized using 1H NMR, 13C NMR, IR, and elemental analysis.
GRAPHICAL ABSTRACT
Acknowledgments
We thank Abdulai Yahuza Nantomah (Pan African University, Institute of Life and Earth Sciences including Health and Agriculture-University of Ibadan) and editing office of Erciyes University for critical reviews of the manuscript.
Author’s contribution
F. Ö. Güney conducted all experiments under the supervision of İ. Ö. İlhan and S. Akkoç, İ. Ö. İlhan designed the study, and S. Akkoç helped analyze data and wrote the manuscript.
Disclosure statement
No potential conflict of interest was reported by the authors.