Synthesis of nine potential synthetic cannabinoid metabolites with a 5F-4OH pentyl side chain from a scalable key intermediate

Abstract

Synthetic cannabinoid metabolites with a 5F-4OH pentyl side chain are of great interest, and several synthetic methods have been developed for the synthesis of these types of metabolites in the literature, which is either lengthy or inappropriate for upscaling. Herein, a straightforward method has been developed and reported for the synthesis of a key intermediate in four steps with an overall yield of 49% on a multigram scale, and its application in the synthesis of nine potential metabolites of synthetic cannabinoids with a 5F-4OH pentyl side chain.

Graphical Abstract

Keywords:

• Key intermediate
• metabolite
• multigram scale
• synthetic cannabinoids

Additional information

Funding

This study was supported by the Strategic Research Area Forensic Sciences, the Swedish Governmental Agency for Innovation Systems, and the Eurostars-2 Joint Programme [E! 113377] with co-funding from the European Union's Horizon 2020 research and innovation programme.