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Abstract
Ruthenium catalyzed oxidative dearomatization-alkoxylation of N-Boc indoles for the synthesis of 2-alkoxyindolin-3-ones was described. The N-Boc indoles can be transformed into 2-alkoxyindolin-3-ones with RuCl3·3H2O as catalyst and tert-butyl hydroperoxide (TBHP, 3.0 equiv) as oxidant in dichloromethane/alcohol. Furtherly, the mechanism had been proposed on the basis of control experiments and isolation of intermediates.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the author(s).
Supporting information
Full experimental detail, 1H and 13C NMR spectra. This material can be found via the “Supplementary Content” section of this article’s webpage.
Additional information
Funding
The work was supported by the Foundation of Guizhou Educational Committee [Grant No. qianjiaohe KY zi [2019] 081], the Natural Science Foundation of Guizhou Province [Grant No. qiankehejichu [2018] number 1141] and the Natural Science Foundation of Liupanshui City [Grant No. 52020-2018-04-10].