https://orcid.org/0000-0003-0572-6305
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Abstract
Current work describes the environmentally benign approach for the synthesis of o-ureidobenzonitriles, from o-aminobenzamides and isothiocyanates using T3P. Here, the conversion of thiourea to urea and amide to nitrile take place simultaneously via unprecedented intramolecular rearrangement. This protocol is operationally facile and offers wide variety of o-ureidobenzonitriles at room temperature in good to excellent yields.
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Additional information
Funding
The author S.S. thank the UGC, New Delhi for the financial support in the form of UGC-JRF/SRF fellowship [Order no. 143540]. Financial support from the VGST Project [Grant No. Ksteps/VGST/GRD-681/KFIST(L1)/2018, dated: 27-08-2018] and PURSE grant [Grant No. PURSE/Phase 2/27(C), dated: 13/09/2019 and PURSE/Phase 2/27(G), dated: 01/10/2019] are also gratefully acknowledged.