One-pot three-component synthesis of a new series of tetrahydrobenzofuran-chromone conjugates

Abstract

An efficient one-pot three-component protocol for the synthesis of novel tetrahydrobenzofuran-chromone conjugates using 3-formylchromones and 1,3-cyclohexandiones in the presence of a variety of alkyl or aryl isocyanides was developed. The reaction sequence consists of an initial Knoevenagel condensation of aromatic aldehydes with 1,3-cyclohexandione derivatives, followed by a [4 + 1] cycloaddition of with isocyanides, and then imine-enamine tautomerization to afford the products.

Graphical Abstract

Keywords:

• Isocyanide
• multicomponent reactions
• tetrahydrobenzofuran-chromone conjugate

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The authors gratefully acknowledge the financial support of Kharazmi University [Grant Number D/2047].