One-pot, two-step synthesis of substituted triazoloquinoxalinone starting from 3-hydrazineylquinoxalin-2(1H)-one

Abstract

An efficient one-pot two-step synthesis of substituted-triazolo[4,3-a]quinoxalin-4(5H)-one has been developed. The 3-hydrazineylquinoxalin-2(1H)-one reacts with respective aldehyde to afford the individual hydrazineylidene intermediate which undergoes oxidative cyclization in the presence of ferric chloride hexahydrate (FeCl₃.6H₂O) to affords various substituted- triazolo[4,3-a]quinoxalin-4(5H)-one in good to excellent yields.

Graphical Abstract

Keywords:

• Hydrazine
• ferric chloride
• 3-hydrazineylquinoxalin-2(1H)-one

Acknowledgment

We are extremely thankful to VFSTR University for financial support and analytical facilities for the execution of this research work. My special thanks to Dr. Arunendra Pathak for helping us whenever we required.

Additional information

Funding

The present research was financially supported by Vignan’s Foundation for Science, Technology and Research.