KO^tBu-BF₃.OEt₂ mediated synthesis of quinazolin-4(3H)-ones from 2-substituted amides with nitriles and aldehydes

Abstract

KO^tBu-BF₃.OEt₂ mediated synthesis of quinazolin-4(3H)-ones from 2-substituted amides with nitriles and aldehydes have been developed. In this protocol, a variety of nitriles as well as aldehydes react with 2-substituted benzamides to corresponding quinazolin-4(3H)-ones products in good to moderate yields, via the cleavage of C-X and C-N bonds and the formation of double C-N bonds simultaneously, in presence of potassium tert-butoxide.

Graphical Abstract

Keywords:

• Nitriles
• aldehydes
• KOtBu
• quinazolinones
• metal-free conditions

Additional information

Funding

CSIR-IICT Communication No. 432/2019. V. N. is thankful to CSIR and S.N.R thankful to SERB-NPDF, New Delhi for their fellowship. We thank DST, Government of India [EMR/2016/000010] and CSIR-IICT for financial support.