Convenient and highly efficient microwave-assisted synthesis of 2-Arylimidazo[1,2-a]pyrimidine-3-carbaldehydes in glycerol

Abstract

A simple and highly efficient method adopted for the synthesis of 2-Arylimidazo[1,2-a]pyrimidine-3-carbaldehyde from reaction of 2-phenylimidazo[1,2-a]pyrimidines, with (Vilsmeier–Haack reagent) in the presence of glycerol as a green reaction medium under microwave irradiation at 400 watt, at 90 °C. Mild reaction conditions, high yield, short reaction time, a clean reaction profile, avoiding toxic catalysts, hazardous organic solvents, and less waste materials are the advantages over the previously adopted method.

Graphical Abstract

Keywords:

• Glycerol
• Imidazo[1
• 2-a]pyrimidine-3-carbaldehyde
• microwave irradiation
• Vilsmeier–Haack reaction

Acknowledgments

We express our sincere thanks to the principal of Dr. Rafiq Zakaria College for women for providing us with the facilities required for conducting this research work.

Disclosure statement

The authors declare no conflict of interest.

Author contributions

All of the authors made contributions to the writing of the manuscript, and they all approved of its final version.