Abstract
Enol phosphates were prepared from 3-diethylphosphonocoumarin under phase-transfer conditions as altered conditions for tandem hydrogenation / phosphorylation reactions. The optimized reaction conditions are characterized with high regioselectivity for O-phosphorylation and O-acylation. The newly synthesized enol phosphates were fully characterized by NMR Spectroscopic techniques and the single (Z)-isomers were assigned.
Graphical Abstract
Acknowledgments
The authors would like to express their gratitude to Prof. Nestor A. Rodios from Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, for the initial NMR data and MS spectra. The authors wish to express their appreciation to Prof. Athanassios Giannis, University of Leipzig, Germany, for HRMS analyses.