One-pot synthesis of trisubstituted 2-pyrones and polysubstituted phenols through Zn catalyzed cascade of ynone/condensation/elimination reactions

Abstract

An efficient multicomponent method is described for the synthesis of a variety of trisubstituted 2-pyrones and polysubstituted phenols based on the Zn-catalyzed cascade reactions between ynone compounds and active methylene group containing diesters. The synthesis of titled compounds were achieved using Zn-catalyzed ynone synthesis followed by Knoevenagel condensation and elimination. Further, this methodology is applied to accomplish the synthesis of poylsubstuited phenols.

HIGHLIGHTS

1. Palladium and Ligand Free Zinc catalyzed One-Pot Synthesis of tri substituted 2-Pyrones and polysubstituted phenols.

2. Economically liable method to synthesize the tri substituted 2-Pyrones and polysubstituted phenols products.

3. Broad substrate scope.

4. Synthesis of various tri substituted 2-Pyrones and polysubstituted phenols.

Graphical Abstract

Keywords:

• Trisubstituted 2-pyrones
• knoevenagel condensation
• poylsubstuited phenols
• salicylates
• one-pot

Acknowledgements

The authors thank GVKBIO and Hyderabad, for providing the facilities in which this research was performed. In addition, the authors thank Dr YSN and Dr Somesh Sharma for their continuous support.