A simple sequential one-pot synthesis of 4-aryl thiazole-based Schiff bases

Abstract

Thiazole based Schiff base scaffolds in recent years have become the integral part of the drug development. These scaffolds are gaining much importance due to their widespread uses as versatile building blocks for the construction of lead drug molecules. Their excellent biological activities have encouraged us to prepare newer compounds with aryl group in the fourth position of thiazoles incorporating azomethine linkages. The strategies so far reported to obtain 4-aryl thiazoles are time consuming, tedious, and costly. In this context, we report a facile one pot synthetic method to obtain novel 4-aryl thiazoles with excellent yield (83–98%), lesser reaction time (40 min) and under milder conditions with no catalyst and no purification techniques.

Graphical Abstract

Keywords:

• 4-Aryl thiazoles
• milder condition
• Schiff base
• thiazole

Acknowledgement

Authors are sincerely thankful to seed grant and instrumentation facility support of the Vellore Institute of Technology.

Authors’ contributions

Dhanapal Preethi: Investigation, Conceptualization, Writing-Original draft. S. L. Manju: Supervision.

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.