Abstract
An array of conjugated Imidazo[1,2-a]pyridines were synthesized via a one-pot, pseudo-five-component reaction incorporating aryl aldehydes, malononitrile, thiophenol or phenol, and acetophenone or acetyl derivatives stimulated by Montmorillonite K10 clay as an eco-friendly catalyst. The entire procedure involves the formation of two new rings, three C–N bonds, two C-C bonds, and one C–X bond. This strategy enables quick green access to functionally multifaceted imidazo[1,2-a]pyridine analogues while highlighting good yields, pure products, an expedient reaction condition, and the reusability of the catalyst up to two cycles. All of the synthesized compounds were characterized through 1H,13C NMR, mass spectrometry, and infrared spectroscopy techniques.
Acknowledgments
The authors are extremely grateful to the infrastructural financial support under the CURIE program from the WISE-KIRAN division of the Department of Science and Technology, New Delhi, India to IIS (deemed to be University), Jaipur, India (File No. DST/CURIE-02/2023/IISU) and to the MRC, MNIT (Jaipur, India) for providing the NMR instrumentation facilities.
Disclosure statement
The authors report there are no competing interests to declare.
Supplementary Material
Full experimental detail, IR, 1H, 13C NMR, and HRMS spectra of all the synthesized compounds. This material can be found via the “Supplementary Content” section of this article’s webpage.
Data availability statement
The authors confirm that the data supporting the findings of this study are available within the supplementary material of this article.