An efficient four-component protocol for synthesis of poly-substituted pyridines with SiO₂ as a robust recyclable catalyst

Abstract

A four-component protocol for the development of poly-substituted pyridines derivatives by using SiO₂ as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) under milder conditions in a short reaction time of 2-3 hours. The use of a less expensive catalyst makes this protocol more convenient. SiO₂ has been identified as a convenient catalyst for the synthesis and can be reused for up to three cycles.

Graphical Abstract

Keywords:

• SiO₂ catalyst
• poly substituted pyridines
• green chemistry
• heterogeneous catalyst
• four-component reaction

Acknowledgments

The authors would like to thank Dr. Reddy’s Laboratory, APSL Hyderabad for providing facilities to carry out this work.