Oxidation of 1,4-Dihydropyridines and 3,4-Dihydropyrimidin-2(1H)-ones to Substituted Pyridines and Pyrimidinones Using Ca(OCl)₂ in Aqueous Media

Abstract

Abstract

1,4-Dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones obtained from the Hantzsch and Biginelli reactions undergo readily oxidative dehydrogenation by using calcium hypochlorite in very short times. These calcium stimulator drugs were oxidized under reaction conditions next to the in vivo transformations at room temperature.

Keywords:

• Biginelli reaction
• Ca(OCl)2
• 1,4-dihydropyridines
• dihydropyrimidinones
• Hantzsch
• oxidative dehydrogenation

ACKNOWLEDGMENTS

We gratefully thank the Yazd University Research Council for financial support. The authors also warmly thank Mr. Mohammad Javad Kazerooni for the preparation of the oxidant.

Notes

^aIsolated yield.

^bMixture of products.

^aIsolated yield.

^bAll products were known.

^cOnly the pyridine product which in R˭H was isolated.

^aIsolated yield.

^bAll products were known.

Dedicated to Professor Habib Firouzabadi.