Excellent Synthesis of Adipic Acid

Abstract

Abstract

A simple, straightforward, and environmentally benign protocol for the synthesis of adipic acid from oxidation of cyclohexanone with Oxone® in the presence of 0.5 mol% RuCl₃ · nH₂O is reported. The reaction completes within a very short time even at room temperature. The generality of the method is shown successfully for synthesis of other C-5 to C-8 dicarboxylic acids.

Keywords:

• Adipic acid
• oxidation
• Oxone
• ruthenium chloride
• water

ACKNOWLEDGMENTS

Financial grants from the Council of Scientific and Industrial Research [No. 01(1992)/05/EMR-II], the Department of Science and Technology [SR/S1/OC-25/2007], New Delhi, and University Grant Commission, New Delhi, are gratefully acknowledged.

Notes

^aRatio of ketone Oxone RuCl₃ · nH₂O = 1:4:0.005.

^bRatio of alcohol Oxone RuCl₃ · nH₂O = 1:5:0.005.

^cReaction was carried out at RT.

^dAt 70 °C.