Facile AlCl₃-Promoted Catalytic Beckmann Rearrangement of Ketoximes

Abstract

Abstract

Aluminum chloride, an inexpensive and commercially available Lewis acid traditionally employed for Beckmann rearrangement with stoichiometric amounts, has been now found to smoothly promote the Beckmann rearrangement of various ketoximes to the corresponding amides (up to 99% of yield) with 10 mol% catalyst loading in anhydrous acetonitrile under reflux temperature.

Keywords:

• Aluminum chloride
• Beckmann rearrangement
• ketoxime

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Corrigenda

ACKNOWLEDGMENTS

This work was supported by the Natural Science Foundation of China (No. NSFC 20602011), New Century Excellent Talents in University, the Ministry of Education, China (No. NCET-07–0283), and the “111” Project (No. B07023).

Notes

^aOverall yield of isomeric mixtures.

^bOverall yield of isomeric mixtures.

^cOverall yield of isomeric mixtures .

^dOverall yield of isomeric mixtures .