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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 5
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Original Articles

Ferric Chloride–Promoted Efficient and Facile BOC Protection of Amines

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Pages 715-719 | Received 25 Oct 2009, Published online: 31 Jan 2011
 

Abstract

Amines are efficiently protected as their tertiary butyloxycarbonyl (BOC) derivatives under mild reaction condition when reacted with (BOC)2O in the presence of FeCl3. The present method is applicable to a variety of amines including aliphatic, aromatic, and hetero aromatic amines.

Notes

a Products were characterized by comparison with spectroscopic data.

b Isolated yields.

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