Abstract
A simple one-pot synthesis has been developed for the synthesis of 2,4,5-trisubstituted imidazoles using an efficient and recyclable MoO3/SiO2 solid acid catalyst by condensation of benzil or benzoin, benzaldehyde, and ammonium acetate in acetonitrile as a solvent. Using this solid catalyst, the reactions could be carried out under mild reaction conditions with very good yield of imidazoles, up to 95%. This catalyst could be recycled very easily, which makes this methodology environmentally benign.
ACKNOWLEDGMENT
S. V. B. and S. V. N. are thankful to DST, New Delhi, for financial support (SR/FTP/CS-82/2007).
Notes
a Reaction conditions: Temperature 80 °C, benzil or benzoin/aldehyde/NH4OAc:1:1:2.5 mmol.
b Isolated yield of product using benzil.
c Isolated yield of product using benzoin.
d Isolated yield of product after first recycle.
e Isolated yield of product after second recycle.